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  • Added 2 Dec 2016
  • Expires

Ghanaian pregnant women in the Greater Accra Metropolitan Region and Biomarkers for the prediction of preeclampsia.


Objective 1a - To evaluate whether the addition of the biomarkers placental growth factor (PlGF) and Pregnancy Associated Plasma Protein A (PAPP-A) to the prediction model for the development of hypertensive disorders in pregnancy based on clinical characteristics by Antwi et al. increases the sensitivity and specificity. Objective 1b - To determine whether blood collected from a finger prick and stored on filter paper instead of serum prepared from venous blood is equally efficient for the assessment of PlGF and PAPP-A levels in predicting the risk of hypertensive disorders in pregnancy. Objective 2a: To determine early infant outcomes of pregnancies complicated by hypertensive disorders in pregnancies compared to uncomplicated pregnancies. Objective 2b: To determine whether infant outcomes of pregnancies complicated by hypertensive disorders in pregnancy are affected by severity of the disorder, the gestational age at onset of PIH/PE, and with recurring development. . This study has been listed on the Link Registry (http://www.linkregistry.org)

Inclusion Criteria

General population of pregnant less than 17 weeks gestation at two antenatal clinics in Accra, Ghana.


Joyce Browne, Assistant Professor, Julios Global Health, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, J.L.Browne@umcutrecht.nl, +3188755555

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